Indian Scientists Rewrite 50-Year-Old Biological Rule

A new study by researchers from the Bose Institute and Rutgers University challenges the long-standing sigma cycle model of bacterial gene regulation, revealing that the transcription initiation factor σA in Bacillus subtilis remains bound to RNA polymerase throughout transcription. This finding has significant implications for understanding bacterial physiology, stress response, and the development of antibiotics, potentially leading to new strategies for combating infections and harnessing bacteria for useful compounds.

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